研究成果Achievements

2022年

  • Yuka Umeki, Noriaki Ogawa, Yuko Uegaki, Kotaro Saga, Yasufumi Kaneda, Keisuke Nimura
    DNA barcoding and gene expression recording reveal the presence of cancer cells with unique properties during tumor progression
    Cellular and molecular life sciences : CMLS 80(1) 17-17 , 2022 Dec 23.
  • Nakai Y, Miyakawa K, Yamaoka Y, Hatayama Y, Nishi M, Suzuki H, Kimura H, Takahashi H, Kimura Y, Ryo A*
    Generation and Utilization of a Monoclonal Antibody against Hepatitis B Virus Core Protein for a Comprehensive Interactome Analysis
    Microorganisms. 10(12), 2381, 2022
  • Toru Sengoku, Masaaki Shiina, Kae Suzuki, Keisuke Hamada, Ko Sato, Akiko Uchiyama, Shunsuke Kobayashi, Asako Oguni, Hayato Itaya, Kota Kasahara, Hirotomo Moriwaki, Chiduru Watanabe, Teruki Honma, Chikako Okada, Shiho Baba, Tsutomu Ohta, Hozumi Motohashi, Masayuki Yamamoto, Kazuhiro Ogata
    Structural basis of transcription regulation by CNC family transcription factor, Nrf2
    Nucleic Acids Research 50(21) 12543-12557 2022
  • Alexander A. Vinogradov, Yue Zhang, Keisuke Hamada, Jun Shi Chang, Chikako Okada, Hirotaka Nishimura, Naohiro Terasaka, Yuki Goto, Kazuhiro Ogata, Toru Sengoku, Hiroyasu Onaka, Hiroaki Suga
    De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors
    Journal of the American Chemical Society 144(44) 20332-20341 2022
  • Mari Wataya-Kaneda; Yoshiyuki Watanabe; Ayumi Nakamura; Kouji Yamamoto; Kiyoshi Okada; Shinichiro Maeda; Keisuke Nimura; Kotaro Saga; Ichiro Katayama
    Pilot study for the treatment of cutaneous neurofibromas in neurofibromatosis type 1 patients using topical sirolimus gel
    Journal of the American Academy of Dermatology, 88, 4, 877, 880 2022
  • Hirose T*, Sugitani Y, Kurihara H, Kazama H, Kusaka C, Noda T, Takahashi H*, and Shigeo Ohno*
    PAR3 Restricts the Expansion of Neural Precursor Cells by Regulating Hedgehog Signaling
    Development, 149(21):dev199931, 2022
  • Ken Saida, Reza Maroofian, Toru Sengoku, Tadahiro Mitani, Alistair T. Pagnamenta, Dana Marafi, Maha S. Zaki, Thomas J. O’Brien, Ehsan Ghayoor Karimiani, Rauan Kaiyrzhanov, Marina Takizawa, Sachiko Ohori, Huey Yin Leong, Gulsen Akay, Hamid Galehdari, Mina Zamani, Ratna Romy, Christopher J. Carroll, Mehran Beiraghi Toosi, Farah Ashrafzadeh, Shima Imannezhad, Hadis Malek, Najmeh Ahangari, Hoda Tomoum, Vykuntaraju K. Gowda, Varunvenkat M. Srinivasan, David Murphy, Natalia Dominik, Hasnaa M. Elbendary, Karima Rafat, Sanem Yilmaz, Seda Kanmaz, Mine Serin, Deepa Krishnakumar, Alice Gardham, Anna Maw, Tekki Sreenivasa Rao, Sarah Alsubhi, Myriam Srour, Daniela Buhas, Tamison Jewett, Rachel E. Goldberg, Hanan Shamseldin, Eirik Frengen, Doriana Misceo, Petter Stromme, Jose Ricardo Magliocco Ceroni, Chong Ae Kim, Gozde Yesil, Esma Sengenc, Serhat Guler, Mariam Hull, Mered Parnes, Dilek Aktas, Banu Anlar, Yavuz Bayram, Davut Pehlivan, Jennifer E. Posey, Shahryar Alavi, Seyed Ali Madani Manshadi, Hamad Alzaidan, Mohammad Al-Owain, Lama Alabdi, Ferdous Abdulwahab, Futoshi Sekiguchi, Kohei Hamanaka, Atsushi Fujita, Yuri Uchiyama, Takeshi Mizuguchi, Satoko Miyatake, Noriko Miyake, Reem M. Elshafie, Kamran Salayev, Ulviyya Guliyeva, Fowzan S. Alkuraya, Joseph G. Gleeson, Kristin G. Monaghan, Katherine G. Langley, Hui Yang, Mahsa Motavaf, Saeid Safari, Mozhgan Alipour, Kazuhiro Ogata, Andre E.X. Brown, James R. Lupski, Henry Houlden, Naomichi Matsumoto
    Brain monoamine vesicular transport disease caused by homozygous SLC18A2 variants: A study in 42 affected individuals
    Genetics in Medicine 25(1) 90-102 2022
  • Abe E, Yamashita A*, Hirota K, Yamaji T, Azushima K, Urate S, Suzuki T, Tanaka S, Taguchi S, Tsukamoto S, Uehara T, Wakui H, Tamura K, Takahashi H
    Angiotensin II type-1 receptor-associated protein interacts with transferrin receptor-1 and promotes its internalization
    Sci Rep. 12(1):17376, 2022
  • Yuchen Zhang, Keisuke Hamada, Dinh Thanh Nguyen, Sumika Inoue, Masayuki Satake, Shunsuke Kobayashi, Chikako Okada, Kazuhiro Ogata, Masahiro Okada, Toru Sengoku, Yuki Goto, Hiroaki Suga
    LimF is a versatile prenyltransferase for histidine-C-geranylation on diverse non-natural substrates
    Nature Catalysis 5(8) 682-693 2022
  • Naoki Sumitani; Kyoso Ishida; Kenjiro Sawada; Tadashi Kimura; Yasufumi Kaneda; Keisuke Nimura
    Identification of Malignant Cell Populations Associated with Poor Prognosis in High-Grade Serous Ovarian Cancer Using Single-Cell RNA Sequencing
    Cancers, 14, 15 2022
  • Koji Kitamura; Hidefumi Suzuki; Ryota Abe; Hidenori Inohara; Yasufumi Kaneda; Hidehisa Takahashi; Keisuke Nimura
    Dual function of SF3B2 on chromatin and RNA to regulate transcription in head and neck squamous cell carcinoma
    Cell & bioscience 12, 1, 92, 92 2022
  • Hidefumi Suzuki, Ryota Abe, Miho Shimada, Tomonori Hirose, Hiroko Hirose, Keisuke Noguchi, Yoko Ike, Nanami Yasui, Kazuki Furugori, Yuki Yamaguchi, Atsushi Toyoda, Yutaka Suzuki, Tatsuro Yamamoto, Noriko Saitoh, Shigeo Sato, Chieri Tomomori-Sato, Ronald C. Conaway, Joan W. Conaway & Hidehisa Takahashi
    The 3′ Pol II pausing at replication-dependent histone genes is regulated by Mediator through Cajal bodies’ association with histone locus bodies
    Nature Communications (2022) 13:2905